Advanced Glycation End-products (AGE) Studies

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Cameron NE, et al (2005) Inhibitors of advanced glycation end product formation and neurovascular dysfunction in experimental diabetes. Ann N Y Acad Sci. Jun;1043:784-92.

Cipollone F, et al, (2003) The receptor RAGE as a progression factor amplifying arachidonate-dependent inflammatory and proteolytic response in human atherosclerotic plaques: role of glycemic control. Circulation Sep 2;108(9):1070-7

Chou SM, Wang HS, Taniguchi A, Bucala R. (1998) Advanced glycation end products in neurofilament conglomeration of motoneurons in familial and sporadic amyotrophic lateral sclerosis. Mol. Med. 4: 324-332.

Degenhardt TP, et al, (2002) Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat. Kidney Int. Mar;61(3):939-50.

Frank T, Bitsch R, Maiwald J, Stein G. (1999) Alteration of thiamine pharmacokinetics by end-stage renal disease (ESRD). Int J Clin Pharmacol Ther. Sep;37(9):449-55.

Greb A, Bitsch R. (1998) Comparative bioavailability of various thiamine derivatives after oral administration. Int J Clin Pharmacol Ther. Apr;36(4):216-21.

Hammes HP, et al (2003) Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nat Med. Mar;9(3):294-9.

Haupt E, et al (2005) Benfotiamine in the treatment of diabetic polyneuropathy--a three-week randomized, controlled pilot study. Int J Clin Pharmacol Ther. Feb;43(2):71-7.

Kakuta T, et al, (2005) Pyridoxamine improves functional, structural, and biochemical alterations of peritoneal membranes in uremic peritoneal dialysis rats. Kidney Int. Sep;68(3):1326-36.

Kanauchi M, Tsujimoto N, Hashimoto T, (2001) Advanced Glycation End Products in Nondiabetic Patients With Coronary Artery Disease. Diabetes Care 24:1620-1623.

Karachalias N, et al, (2005) High-dose thiamine therapy counters dyslipidemia and advanced glycation of plasma protein in streptozotocin-induced diabetic rats. Ann N Y Acad Sci. Jun;1043:777-83.

Kume S, Takeya M, Mori T, (1995) Immunohistochemical and ultrastructural detection of advanced glycation end products in atherosclerotic lesions of human aorta with a novel specific monoclonal antibody. Amer. J. of Pathol. 147: 654-667.

Loew D. (1996) Pharmacokinetics of thiamine derivatives especially of benfotiamine. Int J Clin Pharmacol Ther. Feb;34(2):47-50.

Metz TO, et al (2003) Pyridoxamine traps intermediates in lipid peroxidation reactions in vivo: evidence on the role of lipids in chemical modification of protein and development of diabetic complications. J Biol Chem. Oct 24;278(43):42012-9.

Nagaraj RH, et al (2002) Effect of pyridoxamine on chemical modification of proteins by carbonyls in diabetic rats: characterization of a major product from the reaction of pyridoxamine and methylglyoxal. Arch Biochem Biophys. Jun 1;402(1):110-9.

Nakamura Y, Horii Y, Nishino T, et al, (1993) Immunohistochemical localization of advanced glycosylation end products in coronary atheroma and cardiac tissue in diabetes mellitus. Amer. J. of Pathol. 143: 1649-1656.

Onorato JM et al (2000) Pyridoxamine, an inhibitor of advanced glycation reactions, also inhibits advanced lipoxidation reactions. Mechanism of action of pyridoxamine. J Biol Chem. Jul 14;275(28):21177-84.

Paolisso G, et al, (1994) Plasma vitamin C affects glucose homeostasis in healthy subjects and in non-insulin-dependent diabetics. Am J Physiol Endocrinol Metab. 266: E261-E268.

Sanchez-Ramirez GM, et al, (2006) Benfotiamine relieves inflammatory and neuropathic pain in rats. Eur J Pharmacol. Jan 13;530(1-2):48-53.

Sasaki N, Fukatsu R, Tsuzuki K, et al. (1998) Advanced glycation end products in Alzheimer’s disease and other neurodegenerative diseases. Am J. Pathol. 153: 1149-1155.

Shibata N, Hirano A, Kato S, et al. (1999) Advanced glycation endproducts are deposited in neuronal hyaline inclusions: a study of familia amyotrophic sclerosis with superoxide dismutase-1 mutation. Acta Neuropathol. 97: 240-246.

Scheinman JI, et al (2005) Pyridoxamine lowers oxalate excretion and kidney crystals in experimental hyperoxaluria: a potential therapy for primary hyperoxaluria. Urol Res. Nov;33(5):368-71.

Smith MA, Taneda S, Richey PL, et al. (1994) Advanced Maillard reaction end products are associated with Alzheimer disease pathology. Proc. Natl. Acad. Sci. USA 91: 5710-5714.

Stracke H, Hammes HP, et al. (2001) Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats. Exp Clin Endocrinol Diabetes 109(6):330-6.

Stitt A, et al, (2002) The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes. Diabetes Sep;51(9):2826-32.

Vitek MP, Bhattacharya K, Glendening JM, et al. (1994) Advanced glycation end products contribute to amyloidosis in Alzheimer disease. Proc Natl. Acad. Sci. USA 91: 4766-4770.

Vlassara H. (1997) Recent progress in advanced glycation end products and diabetic complications. Diabetes 46: 519-525.

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Voziyan PA, Hudson BG (2005) Pyridoxamine: the many virtues of a maillard reaction inhibitor. Ann N Y Acad Sci. Jun;1043:807-16.

Yamagishi S, Nakamura K, Inoue H. (2005) Possible participation of advanced glycation end products in the pathogenesis of osteoporosis in diabetic patients. Med Hypotheses. 65(6):1013-5.

Yan SD, Chen X, Schmidt AM, et al. (1994) Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress. Proc. Natl. Acad. Sci. USA 91: 7787-7791.

Yang S, Litchfield JE, Baynes JW. (2003) AGE-breakers cleave model compounds, but do not break Maillard crosslinks in skin and tail collagen from diabetic rats. Arch Biochem Biophys. Apr 1;412(1):42-6.